Hydrogen Bromide → HCID 13338342, compound

HRID 2417564Notes

Reaction equation

HRID 2417564 reaction equation
C[O:2][C:3]1[C:13]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8][C:7]=2[CH:6]=[CH:5][CH:4]=1.[BrH:14]>C(#N)C>[BrH:14].[OH:2][C:3]1[C:13]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8][C:7]=2[CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 138533586-Methoxy-2,3,4,5-tetrahydro-1H-3-benzazepine

Product 1

HCID 13338342HCID 13338342, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The 6-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepine (1.00 g; 0.0056 mol) was heated at reflux in 15 ml of 48% hydrobromic acid, overnight, under argon. It was concentrated to obtain a brown solid which was dispersed in acetonitrile; the mixture was filtered and the solid dried to give 0.94 g of 6-hydroxy-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide, m.p. 220°-224°.

Workup

  1. concentrationIt was concentrated
  2. customto obtain a brown solid which
  3. filtrationthe mixture was filtered
  4. customthe solid dried

Sources & evidence

ORD record
ord-74d9b9c8f70c4d4c804a23e84e093147
Source dataset
uspto-grants-1984_09
Patent number
US04469634

Reaction notes

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