Dimethylformamide dimethyl acetal → HCID 73165729, compound

HRID 2417573Notes

Reaction equation

HRID 2417573 reaction equation
[Cl:1][C:2]1[CH:21]=[CH:20][C:5]2[C:6](=[O:19])[CH2:7][CH2:8][N+:9]([O-:18])=[C:10]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[F:17])[C:4]=2[CH:3]=1.CO[CH:24](OC)[N:25]([CH3:27])[CH3:26]>CCOCC>[Cl:1][C:2]1[CH:21]=[CH:20][C:5]2[C:6](=[O:19])[C:7](=[CH:24][N:25]([CH3:27])[CH3:26])[CH2:8][N+:9]([O-:18])=[C:10]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[F:17])[C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 13094329HCID 13094329, compound

Product 1

HCID 73165729HCID 73165729, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A mixture of 3.4 g (11 mmole) of 8-chloro-1-(2-fluorophenyl)-3,4-dihydro-5H-2-benzazepin-5-one-2-oxide and 26 ml of dimethylformamide dimethyl acetal was stirred at room temperature for 12 hr. The mixture was diluted with ether and the precipitate collected to give a yellow solid, mp 175°-178° C. Recrystallization from a mixture of ether and ethyl acetate gave yellow needles, mp 193°-194° C.

Workup

  1. customthe precipitate collected
  2. customto give a yellow solid, mp 175°-178° C
  3. customRecrystallization
  4. additionfrom a mixture of ether and ethyl acetate
  5. customgave yellow needles, mp 193°-194° C.

Sources & evidence

ORD record
ord-98eccc83306f43e4a31c0231512f807a
Source dataset
uspto-grants-1984_09
Patent number
US04469633

Reaction notes

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