HCID 178430796, compound → HCID 178460861, compound

HRID 2417582Notes

Reaction equation

HRID 2417582 reaction equation
CC1(C)[NH:6][CH:5]([PH:7](=[O:9])[OH:8])[C:4]([CH3:11])([CH3:10])[S:3]1>O.C(O)(C)C>[NH2:6][CH:5]([PH:7](=[O:8])[OH:9])[C:4]([SH:3])([CH3:11])[CH3:10]

Participants

4

Reactant 1

HCID 178430796HCID 178430796, compound

Product 1

HCID 178460861HCID 178460861, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 3776IsopropanolSolvent

Procedure

1.5 g of DL-(2,2,5,5-tetramethyl-4-thiazolidinyl)-phosphinic acid were dissolved in 10 ml of boiling water and the volume was reduced by boiling for 0.25 hour. The mixture was cooled to room temperature and diluted with 25 ml of isopropanol. The resulting mixture was cooled at 0° C. overnight. The resulting solid was collected, washed with isopropanol and dried to give 0.85 g of DL-(1-amino-2-mercapto-2-methylpropyl)phosphinic acid of melting point 211° C. (decomposition).

Workup

  1. temperatureThe resulting mixture was cooled at 0° C. overnight
  2. customThe resulting solid was collected
  3. washwashed with isopropanol
  4. customdried

Sources & evidence

ORD record
ord-d55bb5582c5e4f4380db58526aeddf0b
Source dataset
uspto-grants-1984_09
Patent number
US04469686

Reaction notes

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