L-Hydroxyproline → HCID 45116093, compound

HRID 2417649Notes

Reaction equation

N1CCC[C@H:2]1[C:3](O)=[O:4].[OH:9][C@H:10]1[CH2:14][NH:13][C@H:12]([C:15]([OH:17])=[O:16])[CH2:11]1>>[OH:4][CH2:3][CH2:2][N:13]1[CH2:14][C@H:10]([OH:9])[CH2:11][C@H:12]1[C:15]([OH:17])=[O:16]

Participants

Reactant 2

HCID 5810L-Hydroxyproline

HCID 145742L-Proline

Product 1

HCID 45116093HCID 45116093, compound

Procedure

The procedure was as in Example 5 but in place of (2S)-proline there were employed 39.3 grams of (2S, 4R)-4-hydroxy-proline (0.3 mole). There were obtained 35.4 grams (67.4% of theory) of colorless crystals of (2S, 4R)-N-(2-hydroxyethyl)-4-hydroxy-proline.

Sources & evidence

ORD record: ord-16b0904663e247fab4cc24a906544927
Source dataset: uspto-grants-1984_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04469875

Reaction notes

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