Lithium → HCID 53825399, compound

HRID 2417652Notes

Reaction equation

HRID 2417652 reaction equation
[F:1][C:2]([F:22])([F:21])[C:3]1[CH:20]=[CH:19][C:6]([O:7][C:8]2[CH:18]=[CH:17][C:11]([O:12][CH:13]([CH3:16])[CH:14]=[O:15])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1.[Li].[CH3:24][N:25]([CH3:31])[N:26]=[C:27]([CH2:29][CH3:30])[CH3:28]>>[CH3:24][N:25]([CH3:31])[N:26]=[C:27]([CH2:28][CH:14]([OH:15])[CH:13]([O:12][C:11]1[CH:17]=[CH:18][C:8]([O:7][C:6]2[CH:19]=[CH:20][C:3]([C:2]([F:21])([F:22])[F:1])=[CH:4][CH:5]=2)=[CH:9][CH:10]=1)[CH3:16])[CH2:29][CH3:30]

Participants

4

Reactant 3

HCID 3028194LithiumHCID 128567812-[4-(4-Trifluoromethylphenoxy)phenoxy]propanalHCID 544291102-butanone N,N-dimethylhydrazone

Product 1

HCID 53825399HCID 53825399, compound

Procedure

Following the procedure of Example 1, 2-[4-(4-trifluoromethylphenoxy)phenoxy]propanal is reacted with the lithium salt of 2-butanone N,N-dimethylhydrazone to give 5-hydroxy-6-[4-(4-trifluoromethylphenoxy)phenoxy]-3-heptanone N,N-dimethylhydrazone (cpd. 9, Table A). This hydrazone is then hydrolyzed to 5-hydroxy-6-[4-(4-trifluoromethylphenoxy)phenoxy]-3-heptanone (cpd. 9, Table B).

Sources & evidence

ORD record
ord-47d848c234ab4dfb8188f81b9e3d6f12
Source dataset
uspto-grants-1984_09
Patent number
US04469872

Reaction notes

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