Pyridine → 4-Acetoxy-5-[4-(4-trifluoromethylphenoxy)phenoxy]-2-hexanone

HRID 2417653Notes

Reaction equation

HRID 2417653 reaction equation
[OH:1][CH:2]([CH:7]([O:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][C:17]2[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][CH:18]=2)=[CH:12][CH:11]=1)[CH3:8])[CH2:3][C:4](=[O:6])[CH3:5].N1C=CC=CC=1.[C:33](Cl)(=[O:35])[CH3:34]>C1C=CC=CC=1>[C:33]([O:1][CH:2]([CH:7]([O:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][C:17]2[CH:18]=[CH:19][C:20]([C:23]([F:24])([F:25])[F:26])=[CH:21][CH:22]=2)=[CH:12][CH:11]=1)[CH3:8])[CH2:3][C:4](=[O:6])[CH3:5])(=[O:35])[CH3:34]

Participants

5

Reactant 3

HCID 1049PyridineHCID 6367Acetyl chlorideHCID 202783992-Hexanone, 4-hydroxy-5-[4-[4-(trifluoromethyl)phenoxy]phenoxy]-

Product 1

HCID 204475784-Acetoxy-5-[4-(4-trifluoromethylphenoxy)phenoxy]-2-hexanone

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent2×

Procedure

To 4-hydroxy-5-[4-(4-trifluoromethylphenoxy)phenoxy]-2-hexanone (3.5 mmol) and pyridine (3.5 mmol) in benzene (20 ml) is added acetyl chloride (4.0 mmol). The mixture is stirred at RT overnight. The reaction mixture is diluted with benzene, washed with water, dried and the solvent is removed in vacuo to give 4-acetoxy-5-[4-(4-trifluoromethylphenoxy)phenoxy]-2-hexanone (cpd. 10, Table B).

Workup

  1. washwashed with water
  2. customdried
  3. customthe solvent is removed in vacuo

Sources & evidence

ORD record
ord-7d1e9c4b207346218f70982fb44a6b24
Source dataset
uspto-grants-1984_09
Patent number
US04469872

Reaction notes

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