HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → HCID 13338380, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | 1,3,5-Trimethyl-7-(2-methylaziridin-1-yl)-1H-pyrazolo[4,3-d]pyrimidine | HCID 14006565 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 13338380 | HCID 13338380 | 57.5% |
Reaction Steps
The above aziridine (4.4 g, 0.02 mol) in 50 ml of acetone is stirred under reflux with 3.5 g of sodium iodide for three hours and evaporated in vacuo. The residue is partitioned in 150 ml of methylene dichloride and 50 ml of 20% aqueous sodium carbonate solution. The organic layer is separated, dried (MgSO4) and evaporated in vacuo. The resulting solid is recrystallized from acetonitrile to give 2.5 g of the title compound, mp 169°-172° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04469868 |
| Source dataset | uspto-grants-1984_09 |
| ORD ID | ord-0dd2833f88254e358151c0255e777577 |
| Source note | uspto-grants-1984_09 |