Ammonium Hydroxide → HCID 13338422, compound

HRID 2417663Notes

Reaction equation

HRID 2417663 reaction equation
Cl[C:2]1[C:3]2[N:11]([CH3:12])[N:10]=[C:9]([CH3:13])[C:4]=2[N:5]=[C:6]([CH3:8])[N:7]=1.[NH2:14][CH:15]([CH2:18][CH3:19])[CH2:16][OH:17].[OH-].[NH4+]>C1(C)C=CC=CC=1>[CH3:12][N:11]1[C:3]2[C:2]([NH:14][CH:15]([CH2:18][CH3:19])[CH2:16][OH:17])=[N:7][C:6]([CH3:8])=[N:5][C:4]=2[C:9]([CH3:13])=[N:10]1

Participants

5

Reactant 3

HCID 14923Ammonium HydroxideHCID 221292-Amino-1-butanolHCID 133384077-Chloro-1,3,5-trimethyl-1H-pyrazolo[4,3-d]pyrimidine

Product 1

HCID 13338422HCID 13338422, compoundYield 30.1%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 8 g (0.04 mol) of 7-chloro-1,3,5-trimethyl-1H-pyrazolo[4,3-d]pyrimidine (Ex. 3) and 9 g (0.1 mol) of 2-amino-1-butanol in 75 ml of toluene is heated on the steam bath four hours. The warm solution is shaken with 100 ml of 4N ammonium hydroxide. The aqueous extract is concentrated in vacuo to give 3 g of 2-[1,3,5-trimethyl-1-H-pyrazolo[4,3-d]pyrimidin-7-yl]amino-1-butanol, mp 165°-168° C. Another 2.2 g of product is obtained by concentrating the toluene solution.

Workup

  1. temperatureis heated on the steam bath four hours
  2. extractionThe aqueous extract
  3. concentrationis concentrated in vacuo

Sources & evidence

ORD record
ord-57062a4cfad54e8f8747450cc0ca1c5c
Source dataset
uspto-grants-1984_09
Patent number
US04469868

Reaction notes

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