HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → HCID 13338388, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 7-(Aziridin-1-yl)-5-ethyl-1,3-dimethyl-1H-pyrazolo[4,3-d]pyrimidine | HCID 20447545 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 13338388 | HCID 13338388 | 38% |
Reaction Steps
The above aziridine (6 g, 0.03 mol) is dissolved in 100 ml of acetone and refluxed with 6 g of sodium iodide for two hours. The solution is evaporated in vacuo. The residue is dissolved in methylene dichloride, washed with saturated NaHCO3 solution, dried over MgSO4, and evaporated in vacuo. The resulting solid (2.3 g, 38% yield) melts at 148°-150° C. after recrystallization from ethyl acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04469868 |
| Source dataset | uspto-grants-1984_09 |
| ORD ID | ord-e5e5b375524f4a9d9b076ce494367937 |
| Source note | uspto-grants-1984_09 |