Sodium Iodide → HCID 13338388, compound

HRID 2417666Notes

Reaction equation

HRID 2417666 reaction equation
[N:1]1([C:4]2[C:5]3[N:14]([CH3:15])[N:13]=[C:12]([CH3:16])[C:6]=3[N:7]=[C:8]([CH2:10][CH3:11])[N:9]=2)[CH2:3][CH2:2]1.[I-].[Na+].C(OCC)(=O)C>CC(C)=O>[CH2:10]([C:8]1[N:9]2[CH2:2][CH2:3][N:1]=[C:4]2[C:5]2[N:14]([CH3:15])[N:13]=[C:12]([CH3:16])[C:6]=2[N:7]=1)[CH3:11]

Participants

5

Reactant 3

HCID 5238Sodium IodideHCID 8857Ethyl AcetateHCID 204475457-(Aziridin-1-yl)-5-ethyl-1,3-dimethyl-1H-pyrazolo[4,3-d]pyrimidine

Product 1

HCID 13338388HCID 13338388, compoundYield 38%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

The above aziridine (6 g, 0.03 mol) is dissolved in 100 ml of acetone and refluxed with 6 g of sodium iodide for two hours. The solution is evaporated in vacuo. The residue is dissolved in methylene dichloride, washed with saturated NaHCO3 solution, dried over MgSO4, and evaporated in vacuo. The resulting solid (2.3 g, 38% yield) melts at 148°-150° C. after recrystallization from ethyl acetate.

Workup

  1. customThe solution is evaporated in vacuo
  2. dissolutionThe residue is dissolved in methylene dichloride
  3. washwashed with saturated NaHCO3 solution
  4. dry with materialdried over MgSO4
  5. customevaporated in vacuo

Sources & evidence

ORD record
ord-e5e5b375524f4a9d9b076ce494367937
Source dataset
uspto-grants-1984_09
Patent number
US04469868

Reaction notes

Loading…