Hydrogen Peroxide → HCID 178437760, compound

HRID 2417667Notes

Reaction equation

HRID 2417667 reaction equation
[C:1]([C:3]1[N:7]([CH3:8])[N:6]=[C:5]([CH3:9])[C:4]=1[NH:10][C:11](=O)[CH2:12][CH3:13])#[N:2].[OH:15]O.O.[OH-].[Na+]>C(O)C.C(O)(=O)C>[CH2:12]([C:11]1[N:2]=[C:1]([OH:15])[C:3]2[N:7]([CH3:8])[N:6]=[C:5]([CH3:9])[C:4]=2[N:10]=1)[CH3:13]

Participants

7

Reactant 4

HCID 784Hydrogen PeroxideHCID 962WaterHCID 14798Sodium HydroxideHCID 14006553N-(5-Cyano-1,3-dimethyl-1H-pyrazol-4-yl)propanamide

Product 1

HCID 178437760HCID 178437760, compoundYield 70%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

The above propionamide (18 g, 0.094 mol) is added in portions to a solution prepared by adding 24 ml of 30% hydrogen peroxide to 250 ml of water containing 6 g (0.15 mol) of sodium hydroxide. The mixture is stirred at 80° C. for five hours, cooled and acidified with acetic acid to give 12.7 g (70%) of 5-ethyl-1,3-dimethyl-1H-pyrazolo[4,3-d]pyrimidin-7-ol, mp 220°-222° C. from ethanol.

Workup

  1. customprepared
  2. temperaturecooled

Sources & evidence

ORD record
ord-369637e5b8cb4812b15d2c0173296f6d
Source dataset
uspto-grants-1984_09
Patent number
US04469868

Reaction notes

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