Sodium Iodide → HCID 13338393, compound

Participants

Reaction Steps

The aziridine (6.7 g, 0.027 mol) in 100 ml of acetone is refluxed two hours with 4.5 g (0.03 mol) of sodium iodide and the mixture is evaporated in vacuo. The residue is partitioned in 100 ml of methylene dichloride and 50 ml of saturated sodium bicarbonate solution. The organic layer is separated, dried over magnesium sulfate, and evaporated in vacuo. The oil is crystallized from pet ether to give 3.6 g (54%) mp 96°-97° C. of 7,8-dihydro-5-isopropyl-1,3,8-trimethyl-1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidine.

Provenance & Evidence