Sodium Iodide → HCID 13338393, compound

HRID 2417672Notes

Reaction equation

HRID 2417672 reaction equation
[CH3:1][N:2]1[C:10]2[C:9]([N:11]3[CH2:13][CH:12]3[CH3:14])=[N:8][C:7]([CH:15]([CH3:17])[CH3:16])=[N:6][C:5]=2[C:4]([CH3:18])=[N:3]1.[I-].[Na+]>CC(C)=O>[CH:15]([C:7]1[N:8]2[CH2:14][CH:12]([CH3:13])[N:11]=[C:9]2[C:10]2[N:2]([CH3:1])[N:3]=[C:4]([CH3:18])[C:5]=2[N:6]=1)([CH3:16])[CH3:17]

Participants

4

Reactant 2

HCID 5238Sodium IodideHCID 14006567HCID 14006567, compound

Product 1

HCID 13338393HCID 13338393, compoundYield 54.4%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

The aziridine (6.7 g, 0.027 mol) in 100 ml of acetone is refluxed two hours with 4.5 g (0.03 mol) of sodium iodide and the mixture is evaporated in vacuo. The residue is partitioned in 100 ml of methylene dichloride and 50 ml of saturated sodium bicarbonate solution. The organic layer is separated, dried over magnesium sulfate, and evaporated in vacuo. The oil is crystallized from pet ether to give 3.6 g (54%) mp 96°-97° C. of 7,8-dihydro-5-isopropyl-1,3,8-trimethyl-1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidine.

Workup

  1. customthe mixture is evaporated in vacuo
  2. customThe residue is partitioned in 100 ml of methylene dichloride
  3. customThe organic layer is separated
  4. dry with materialdried over magnesium sulfate
  5. customevaporated in vacuo
  6. customThe oil is crystallized from pet ether

Sources & evidence

ORD record
ord-f018dc9efbb6458998b07eb4850cd0f5
Source dataset
uspto-grants-1984_09
Patent number
US04469868

Reaction notes

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