HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanolamine → HCID 13338426, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanolamine | HCID 700 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 7-Chloro-1-ethyl-3,5-dimethyl-1H-pyrazolo[4,3-d]pyrimidine | HCID 13338409 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 13338426 | HCID 13338426 | 56.7% |
Reaction Steps
A solution of 12 g (0.057 mol) of 7-chloro-3,5-dimethyl-1-ethyl-1H-pyrazolo[4,3-d]pyrimidine in 150 ml of methylene dichloride is treated with 12 g (0.2 mol) of 2-aminoethanol and 8 ml of triethyamine and stirred at room temperature 48 hours. The mixture is filtered to give 7.6 g (56%) of 2-[1-ethyl-3,5-dimethyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl]aminoethanol, mp 181°-183° C. from ethyl acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04469868 |
| Source dataset | uspto-grants-1984_09 |
| ORD ID | ord-f9353231fee9461fa1573b212c9315a6 |
| Source note | uspto-grants-1984_09 |