Ethanolamine → HCID 13338426, compound

HRID 2417679Notes

Reaction equation

HRID 2417679 reaction equation
Cl[C:2]1[C:3]2[N:11]([CH2:12][CH3:13])[N:10]=[C:9]([CH3:14])[C:4]=2[N:5]=[C:6]([CH3:8])[N:7]=1.[NH2:15][CH2:16][CH2:17][OH:18].C(N(CC)CC)C>C(Cl)Cl>[CH2:12]([N:11]1[C:3]2[C:2]([NH:15][CH2:16][CH2:17][OH:18])=[N:7][C:6]([CH3:8])=[N:5][C:4]=2[C:9]([CH3:14])=[N:10]1)[CH3:13]

Participants

5

Reactant 3

HCID 700EthanolamineHCID 8471TriethylamineHCID 133384097-Chloro-1-ethyl-3,5-dimethyl-1H-pyrazolo[4,3-d]pyrimidine

Product 1

HCID 13338426HCID 13338426, compoundYield 56.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 12 g (0.057 mol) of 7-chloro-3,5-dimethyl-1-ethyl-1H-pyrazolo[4,3-d]pyrimidine in 150 ml of methylene dichloride is treated with 12 g (0.2 mol) of 2-aminoethanol and 8 ml of triethyamine and stirred at room temperature 48 hours. The mixture is filtered to give 7.6 g (56%) of 2-[1-ethyl-3,5-dimethyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl]aminoethanol, mp 181°-183° C. from ethyl acetate.

Workup

  1. filtrationThe mixture is filtered

Sources & evidence

ORD record
ord-f9353231fee9461fa1573b212c9315a6
Source dataset
uspto-grants-1984_09
Patent number
US04469868

Reaction notes

Loading…