Formaldehyde → Salicylaldehyde

HRID 2417695Notes

Reaction equation

[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:8]=[O:9]>>[CH:8](=[O:9])[C:2]1[C:1](=[CH:6][CH:5]=[CH:4][CH:3]=1)[OH:7]

Participants

Reactant 2

HCID 712Formaldehyde

HCID 996Phenol

Product 1

HCID 6998Salicylaldehyde

Procedure

A method in which a salicylaldehyde is prepared in good yield by one step reaction using as starting materials a phenol and a formaldehyde and a specific catalyst (a base represented by a tertiary amine and/or an organometallic salt):

Workup

customin good yield by one step reaction

Sources & evidence

ORD record: ord-f2782aff56004489b1837e6fd999992c
Source dataset: uspto-grants-1984_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04469894

Reaction notes

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