Ethyl 4-((4-chloro-2-nitrophenyl)amino)piperidine-1-carboxylate → Ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate

Participants

Reaction Steps

A solution of 59 g of 1-carbethoxy-4-(2-nitro-4-chloroanilino)-piperidine in 270 ml of tetrahydrofuran and 96 ml of absolute ethanol was hydrogenated under normal pressure and at room temperature, using 15 g of Raney nickel as a catalyst. When the uptake of hydrogen had ended, the mixture was filtered and the filtrate was evaporated. Melting point: 150° C.

Provenance & Evidence