Ethyl 4-((4-chloro-2-nitrophenyl)amino)piperidine-1-carboxylate → Ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate

HRID 2417793노트

반응식

HRID 2417793 반응식
[C:1]([N:6]1[CH2:11][CH2:10][CH:9]([NH:12][C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=2[N+:20]([O-])=O)[CH2:8][CH2:7]1)([O:3][CH2:4][CH3:5])=[O:2].[H][H]>O1CCCC1.C(O)C.[Ni]>[C:1]([N:6]1[CH2:7][CH2:8][CH:9]([NH:12][C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=2[NH2:20])[CH2:10][CH2:11]1)([O:3][CH2:4][CH3:5])=[O:2]

참가 물질

6

반응물 2

HCID 104608Ethyl 4-((4-chloro-2-nitrophenyl)amino)piperidine-1-carboxylateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 104609Ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate

시약·촉매·용매 3

HCID 935Nickel촉매HCID 702Ethanol용매HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 59 g of 1-carbethoxy-4-(2-nitro-4-chloroanilino)-piperidine in 270 ml of tetrahydrofuran and 96 ml of absolute ethanol was hydrogenated under normal pressure and at room temperature, using 15 g of Raney nickel as a catalyst. When the uptake of hydrogen had ended, the mixture was filtered and the filtrate was evaporated. Melting point: 150° C.

후처리

  1. customwas hydrogenated under normal pressure and at room temperature
  2. filtrationthe mixture was filtered
  3. customthe filtrate was evaporated

출처 및 근거

ORD 기록
ord-cd3198adf58c421e8c4c8a6348df186c
출처 데이터셋
uspto-grants-1984_09
특허 번호
US04470989

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