Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Iodide → 1-[(Benzo-1,4-dioxan-2-yl)-methyl]-4-(5-chlorobenzimidazole-2-thion-1-yl)-piperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Iodide | HCID 5238 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2-Bromomethyl-1,4-benzodioxane | HCID 98333 | — |
| 반응물 | 5-Chloro-1,3-dihydro-1-(4-piperidinyl)-1H-benzimidazole-2-thione | HCID 3020006 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-[(Benzo-1,4-dioxan-2-yl)-methyl]-4-(5-chlorobenzimidazole-2-thion-1-yl)-piperidine | HCID 13084430 | — |
반응 단계
2.3 g of 2-bromomethyl-1,4-benzodioxane, 2.35 g of 4-(5-chlorobenzimidazole-2-thion-1-yl)-piperidine, 1.4 ml of triethylamine and 0.3 g of sodium iodide were warmed at 60° C. in 25 ml of anhydrous dimethylformamide for 60 hours, and the mixture was then poured onto ice-water. The precipitate which had separated out was filtered off with suction, washed with water and dried.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04470989 |
| 출처 데이터셋 | uspto-grants-1984_09 |
| ORD ID | ord-b618b5938727444287017692b0ce41ed |
| 출처 메모 | uspto-grants-1984_09 |