Hydrogen Bromide → 4-(5-Chloro-2-nitroanilino)-piperidine hydrobromide

HRID 2417801Notes

Reaction equation

HRID 2417801 reaction equation
C([N:6]1[CH2:11][CH2:10][CH:9]([NH:12][C:13]2[CH:18]=[C:17]([Cl:19])[CH:16]=[CH:15][C:14]=2[N+:20]([O-:22])=[O:21])[CH2:8][CH2:7]1)(OCC)=O.[BrH:23]>>[BrH:23].[Cl:19][C:17]1[CH:16]=[CH:15][C:14]([N+:20]([O-:22])=[O:21])=[C:13]([CH:18]=1)[NH:12][CH:9]1[CH2:10][CH2:11][NH:6][CH2:7][CH2:8]1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 137921661-Carbethoxy-4-(5-chloro-2-nitroanilino)-piperidine

Product 1

HCID 204466934-(5-Chloro-2-nitroanilino)-piperidine hydrobromide

Procedure

30 g of 1-carbethoxy-4-(5-chloro-2-nitroanilino)-piperidine in 400 ml of 48% strength hydrobromic acid were boiled under reflux, with stirring, for 4 hours. After the mixture had been cooled, the precipitate which had formed was filtered off with suction and washed with water and petroleum ether. The product was obtained as a light beige powder.

Workup

  1. temperatureunder reflux
  2. temperatureAfter the mixture had been cooled
  3. customthe precipitate which had formed
  4. filtrationwas filtered off with suction
  5. washwashed with water and petroleum ether
  6. customThe product was obtained as a light beige powder

Sources & evidence

ORD record
ord-e4fb7937f6e54a10bd2f0b031c631d9c
Source dataset
uspto-grants-1984_09
Patent number
US04470989

Reaction notes

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