反应详情

A solution of 6-aminomethyl-3-benzyloxy-2-methylpyridine (6.31 g) in 8.7 ml of formic acid is heated at 90° for 15 hours. The reaction mixture is cooled, made basic with ice-cold ammonium hydroxide solution and extracted with chloroform. (3×25 ml). The chloroform extract is dried over sodium sulfate and evaporated. Recrystallization from ether yields 3-benzyloxy-6-formylaminomethyl-2-methylpyridine, m.p. 67°-68°.

1. temperatureThe reaction mixture is cooled
2. extractionextracted with chloroform
3. extractionThe chloroform extract
4. dry with materialis dried over sodium sulfate
5. customevaporated
6. customRecrystallization from ether