HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formic Acid → 3-Benzyloxy-6-formylaminomethyl-2-methylpyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | 6-Aminomethyl-3-benzyloxy-2-methylpyridine | HCID 23321889 | — |
| Product | 3-Benzyloxy-6-formylaminomethyl-2-methylpyridine | HCID 13373637 | — |
Reaction Steps
A solution of 6-aminomethyl-3-benzyloxy-2-methylpyridine (6.31 g) in 8.7 ml of formic acid is heated at 90° for 15 hours. The reaction mixture is cooled, made basic with ice-cold ammonium hydroxide solution and extracted with chloroform. (3×25 ml). The chloroform extract is dried over sodium sulfate and evaporated. Recrystallization from ether yields 3-benzyloxy-6-formylaminomethyl-2-methylpyridine, m.p. 67°-68°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04470986 |
| Source dataset | uspto-grants-1984_09 |
| ORD ID | ord-9e10afa67fbe40fa82cb0b744d2ac28a |
| Source note | uspto-grants-1984_09 |