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HRID2417911

反应详情

EQUATION

反应方程式

HRID 2417911 的结构方程式

REACTANTS

反应物

3
结构：CN(C)C=O
HCID6228

N,N-Dimethylformamide

C3H7NO

结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：O=[N+]([O-])c1ccc(Cl)c(NC(=S)NCCCO)c1
HCID3018734

N-(2-Chloro-5-nitrophenyl)-N'-(3-hydroxypropyl)carbamimidothioic acid

C10H12ClN3O3S

PRODUCTS

生成物

1
结构：O=[N+]([O-])c1ccc2sc(NCCCO)nc2c1
HCID3018735

3-[(5-Nitro-1,3-benzothiazol-2(3H)-ylidene)amino]propan-1-ol

C10H11N3O3S

收率 72.2%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

A mixture of 21 parts of N-(2-chloro-5-nitrophenyl)-N'-(3-hydroxypropyl)thiourea, 10 parts of potassium carbonate and 180 parts of N,N-dimethylformamide is stirred and refluxed for 30 minutes. After cooling, 300 parts of water are added and the product is allowed to crystallize. It is filtered off and washed with water, yielding 13.3 parts (72.2%) of 3-[(5-nitro-2-benzothiazolyl)amino]-1-propanol; mp. 140°-144° C.

WORKUP

后处理

  1. temperaturerefluxed for 30 minutes
  2. temperatureAfter cooling
  3. customto crystallize
  4. filtrationIt is filtered off
  5. washwashed with water