Ammonia → HCID 13338582, compound

Participants

Reaction Steps

A mixture of 14 parts of 3,4-dihydro-8-nitro-2H-pyrimido[2,1-b]benzothiazole and 400 parts of methanol, saturated with ammonia is hydrogenated at normal pressure and at room temperature with 5 parts of platinum-on-charcoal catalyst 5%. After the calculated amount of hydrogen is taken up, the catalyst is filtered off and the filtrate is evaporated. The residue is crystallized from 2-propanol. The product is filtered off and dried, yielding 9.3 parts of 3,4-dihydro-2H-pyrimido[2,1-b]benzothiazol-8-amine; mp. 186.5° C.

Provenance & Evidence