Ammonia → HCID 13338582, compound

HRID 2417916Notes

Reaction equation

HRID 2417916 reaction equation
[N+:1]([C:4]1[CH:16]=[CH:15][C:7]2[N:8]3[CH2:14][CH2:13][CH2:12][N:11]=[C:9]3[S:10][C:6]=2[CH:5]=1)([O-])=O.N.[H][H]>[Pt].CO>[N:11]1[CH2:12][CH2:13][CH2:14][N:8]2[C:7]3[CH:15]=[CH:16][C:4]([NH2:1])=[CH:5][C:6]=3[S:10][C:9]=12

Participants

6

Reactant 3

HCID 222AmmoniaHCID 13338576HCID 13338576, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 13338582HCID 13338582, compound

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 14 parts of 3,4-dihydro-8-nitro-2H-pyrimido[2,1-b]benzothiazole and 400 parts of methanol, saturated with ammonia is hydrogenated at normal pressure and at room temperature with 5 parts of platinum-on-charcoal catalyst 5%. After the calculated amount of hydrogen is taken up, the catalyst is filtered off and the filtrate is evaporated. The residue is crystallized from 2-propanol. The product is filtered off and dried, yielding 9.3 parts of 3,4-dihydro-2H-pyrimido[2,1-b]benzothiazol-8-amine; mp. 186.5° C.

Workup

  1. filtrationthe catalyst is filtered off
  2. customthe filtrate is evaporated
  3. customThe residue is crystallized from 2-propanol
  4. filtrationThe product is filtered off
  5. customdried

Sources & evidence

ORD record
ord-31f3c8759a004b6788eedae8bf65d312
Source dataset
uspto-grants-1984_09
Patent number
US04471117

Reaction notes

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