Diethyl (ethoxymethylene)malonate → HCID 20446961, compound

HRID 2417919Notes

Reaction equation

HRID 2417919 reaction equation
[N:1]1[CH2:2][CH2:3][CH2:4][N:5]2[C:9]3[CH:10]=[C:11]([NH2:14])[CH:12]=[CH:13][C:8]=3[S:7][C:6]=12.C(O[CH:18]=[C:19]([C:25]([O:27][CH2:28][CH3:29])=[O:26])[C:20]([O:22][CH2:23][CH3:24])=[O:21])C>>[N:1]1[CH2:2][CH2:3][CH2:4][N:5]2[C:9]3[CH:10]=[C:11]([NH:14][CH:18]=[C:19]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[C:25]([O:27][CH2:28][CH3:29])=[O:26])[CH:12]=[CH:13][C:8]=3[S:7][C:6]=12

Participants

3

Reactant 2

HCID 6871Diethyl (ethoxymethylene)malonateHCID 133385843,4-Dihydro-2H-pyrimido[2,1-b][1,3]benzothiazol-7-amine

Product 1

HCID 20446961HCID 20446961, compoundYield 96%

Procedure

A mixture of 5.13 parts of 3,4-dihydro-2H-pyrimido[2,1-b]benzothiazol-7-amine and 6.5 parts of diethyl 2-(ethoxymethylene)propanedioate is stirred for 30 minutes at 100°-110° C. The product solidifies on triturating in 1,1'-oxybisethane, yielding 9 parts (96%) of diethyl 2-[(3,4-dihydro-2H-pyrimido[2,1-b]benzothiazol-7-yl)aminomethylene]propanedioate.

Workup

  1. customon triturating in 1,1'-oxybisethane

Sources & evidence

ORD record
ord-d3b33d357b8248f78303ace4d2df63c6
Source dataset
uspto-grants-1984_09
Patent number
US04471117

Reaction notes

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