Isopropylamine → 1-Benzyloxy-4-[5-(1-methylethyl)aminopentoxy]benzene

HRID 2417985Notes

Reaction equation

HRID 2417985 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]Br)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:22]([NH2:25])([CH3:24])[CH3:23]>>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][NH:25][CH:22]([CH3:24])[CH3:23])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 6363IsopropylamineHCID 132191241-(Benzyloxy)-4-[(5-bromopentyl)oxy]benzene

Product 1

HCID 204469461-Benzyloxy-4-[5-(1-methylethyl)aminopentoxy]benzene

Procedure

As described in Example 19, 1-benzyloxy-4-(5-bromopentoxy)benzene was reacted with isopropylamine at 100° (12 hours; 150 psi) to give 1-benzyloxy-4-[5-(1-methylethyl)aminopentoxy]benzene. The distilled product was 95.2% pure by gas chromatography.

Sources & evidence

ORD record
ord-cd98b437db8c49509a7dc3fa2f4ac29e
Source dataset
uspto-grants-1984_09
Patent number
US04471116

Reaction notes

Loading…