Isopropylamine → 1-Benzyloxy-4-[6-(1-methylethyl)aminohexyloxy]benzene

HRID 2417986Notes

Reaction equation

HRID 2417986 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]Br)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:23]([NH2:26])([CH3:25])[CH3:24]>>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][NH:26][CH:23]([CH3:25])[CH3:24])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 6363IsopropylamineHCID 134508831-(Benzyloxy)-4-[(6-bromohexyl)oxy]benzene

Product 1

HCID 133384811-Benzyloxy-4-[6-(1-methylethyl)aminohexyloxy]benzene

Procedure

As described in Example 19, 1-benzyloxy-4-(6-bromohexyloxy)benzene was reacted with isopropylamine at 100° (12 hours; 500 psi) to give 1-benzyloxy-4-[6-(1-methylethyl)aminohexyloxy]benzene. The crude oil was crystallized from pentane yielding the purified product, mp 47°-49°.

Sources & evidence

ORD record
ord-a12716c74ce84a73acd2f1c10e98f378
Source dataset
uspto-grants-1984_09
Patent number
US04471116

Reaction notes

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