反应详情

To 48% hydrobromic acid solution (110 g) was added 4-(3-hydroxypropyl)phenol (25 g) and heated on a steam bath for 3 hours. After cooling, water (500 ml) was added, the oil was extracted with ether, washed with water and then with dilute sodium bicarbonate solution. The etheral extract was dried over potassium carbonate, evaporated and the residue was distilled in a Kugelrohr apparatus giving 29.6 g (84%) of 4-(3-bromopropyl)phenol, bp 180° (2 mm). The product was 92.6% pure by gas chromatography and mass spectrum was compatible with 4-(3-bromopropyl)phenol.

1. temperatureheated on a steam bath for 3 hours
2. temperatureAfter cooling
3. extractionthe oil was extracted with ether
4. washwashed with water
5. extractionThe etheral extract
6. dry with materialwas dried over potassium carbonate
7. customevaporated
8. distillationthe residue was distilled in a Kugelrohr apparatus