反应详情

4-[4-methoxyphenyl]-N-(1-methylethyl)butylamine (10 g) was added to 48% hydrobromic acid solution (70 ml) and the mixture was refluxed for 3 hours. The residual hydrobromic hydrogen acid was distilled off in vacuo and the residue was made alkaline with 10% sodium carbonate solution. The product was filtered, washed with water and dried to give 5.0 g of 4-[4-(1-methylethyl)aminobutyl]phenol. Mass spectrum and gas chromatography confirmed the identity and purity (93.5%) of the product.

1. temperaturethe mixture was refluxed for 3 hours
2. distillationThe residual hydrobromic hydrogen acid was distilled off in vacuo
3. filtrationThe product was filtered
4. washwashed with water
5. customdried