反应详情

A stirred solution of 1-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-4-(2-chloroethyl) piperazine (10 g) and 4-[3-(1-methylethyl)aminopropyl]phenol (4.5 g) in 100 ml dimethylsulfoxide containing sodium hydroxide (0.94 g) in water (7 ml) was stirred at 55°-60° for 5 hours. The crude trihydrochloride salt obtained after the usual work-up was crystallized from methanol-acetonitrile to yield 4.5 g of 1-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-4-[2-[4-[3-(1-methylethyl)aminopropyl]phenoxy]ethyl]piperazine trihydrochloride, mp 216°-218°.

1. customThe crude trihydrochloride salt obtained after the usual work-up
2. customwas crystallized from methanol-acetonitrile