HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 1-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-4-[2-[4-[3-(1-methylethyl)aminopropyl]phenoxy]ethyl]piperazine trihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-Chloro-10-[3-[4-(2-chloroethyl)piperazin-1-yl]propyl]phenothiazine | HCID 5275455 | — |
| Reactant | 4-[3-(1-Methylethyl)aminopropyl]phenol | HCID 20446957 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-4-[2-[4-[3-(1-methylethyl)aminopropyl]phenoxy]ethyl]piperazine trihydrochloride | HCID 13338473 | 110.4% |
Reaction Steps
A stirred solution of 1-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-4-(2-chloroethyl) piperazine (10 g) and 4-[3-(1-methylethyl)aminopropyl]phenol (4.5 g) in 100 ml dimethylsulfoxide containing sodium hydroxide (0.94 g) in water (7 ml) was stirred at 55°-60° for 5 hours. The crude trihydrochloride salt obtained after the usual work-up was crystallized from methanol-acetonitrile to yield 4.5 g of 1-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-4-[2-[4-[3-(1-methylethyl)aminopropyl]phenoxy]ethyl]piperazine trihydrochloride, mp 216°-218°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04471116 |
| Source dataset | uspto-grants-1984_09 |
| ORD ID | ord-12068f7132c743829c2805195a25b5e3 |
| Source note | uspto-grants-1984_09 |