Methylamine → Orf 17583

HRID 2418039Notes

Reaction equation

HRID 2418039 reaction equation
COC1C(OC)=NS(=O)N=1.CN.CO[C:15]1[C:19]([NH:20][CH3:21])=[N:18][S:17](=[O:22])[N:16]=1.[CH3:23][N:24]([CH2:26][C:27]1[O:31][C:30]([CH2:32][S:33][CH2:34][CH2:35][NH2:36])=[CH:29][CH:28]=1)[CH3:25]>>[CH3:25][N:24]([CH2:26][C:27]1[O:31][C:30]([CH2:32][S:33][CH2:34][CH2:35][NH:36][C:15]2[C:19]([NH:20][CH3:21])=[N:18][S:17](=[O:22])[N:16]=2)=[CH:29][CH:28]=1)[CH3:23]

Participants

5

Reactant 4

HCID 6329MethylamineHCID 1622035-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamineHCID 129139473,4-Dimethoxy-1,2,5-thiadiazole 1-oxideHCID 200307843-Methoxy-4-methylamino-1,2,5-thiadiazole 1-oxide

Product 1

HCID 5486884Orf 17583

Procedure

Reaction of a methanolic solution of 3,4-dimethoxy-1,2,5-thiadiazole 1-oxide [prepared in Example 4, Step A] with one equivalent of methylamine and treatment of the resultant 3-methoxy-4-methylamino-1,2,5-thiadiazole 1-oxide with one equivalent of 2-[(5-dimethylaminomethyl-2-furyl)methylthio]ethylamine yields the title compound, which is identical to the product prepared in Example 18.

Sources & evidence

ORD record
ord-b16d68f9bb3e4359a1ffa5bb941b0da4
Source dataset
uspto-grants-1984_09
Patent number
US04471122

Reaction notes

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