Methylamine → HCID 178482371, compound

HRID 2418080Notes

Reaction equation

HRID 2418080 reaction equation
COC1C(OC)=NS(=O)(=O)N=1.[NH:12]([C:16]1[O:17][CH:18]=[C:19]([CH2:21][CH2:22][CH2:23][CH2:24][NH2:25])[N:20]=1)[C:13]([NH2:15])=[NH:14].N(C1OC=C(CCC[CH2:38][NH:39][C:40]2(OC)[NH:44][S:43](=[O:46])(=[O:45])[N:42]=[CH:41]2)N=1)C(N)=N.CN>>[NH:12]([C:16]1[O:17][CH:18]=[C:19]([CH2:21][CH2:22][CH2:23][CH2:24][NH:25][C:40]2([NH:39][CH3:38])[NH:44][S:43](=[O:46])(=[O:45])[N:42]=[CH:41]2)[N:20]=1)[C:13]([NH2:15])=[NH:14]

Participants

5

Reactant 4

HCID 6329MethylamineHCID 122305383,4-Dimethoxy-1,2,5-thiadiazole 1,1-dioxideHCID 178494170HCID 178494170, compoundHCID 178512643HCID 178512643, compound

Product 1

HCID 178482371HCID 178482371, compound

Procedure

When a suspension of 3,4-dimethoxy-1,2,5-thiadiazole 1,1-dioxide is reacted with an equimolar amount of 4-[(2-guanidino-4-oxazolyl]butylamine [prepared according to the procedure described in Belgian Pat. No. 866,155] and the resultant 3-{4-[(2-guanidino-4-oxazolyl]butylamino}-4-methoxy-1,2,5-thiadiazole 1,1-dioxide is treated with excess methylamine, the title compound is thereby produced.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-597c5ef5e37249e8b562cd9c70739118
Source dataset
uspto-grants-1984_09
Patent number
US04471122

Reaction notes

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