Cysteamine Hydrochloride → HCID 15592296, compound

HRID 2418101Notes

Reaction equation

HRID 2418101 reaction equation
Cl.[NH2:2][CH2:3][CH2:4][SH:5].Cl.[CH3:7][N:8]([CH3:16])[C:9]1[S:10][CH:11]=[C:12]([CH2:14]Cl)[N:13]=1>Cl>[CH3:7][N:8]([CH3:16])[C:9]1[S:10][CH:11]=[C:12]([CH2:14][S:5][CH2:4][CH2:3][NH2:2])[N:13]=1

Participants

4

Reactant 2

HCID 9082Cysteamine HydrochlorideHCID 20402060162740-04-7

Product 1

HCID 15592296HCID 15592296, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Cysteamine hydrochloride (5.24 g; 45.9 mmoles) and 2-dimethylamino-4-chloromethylthiazole hydrochloride (9.8 g; 45.9 mmoles) [prepared from N,N-dimethylthiourea and 1,3-dichloro-2-propanone] were dissolved in 45 ml of concentrated hydrochloric acid and heated at an oil bath temperature of 100° for 96 hours. The mixture was evaporated under reduced pressure and the residue made basic with 40% aqueous NaOH. The aqueous phase was extracted with methyl acetate, dried and evaporated to give the title compound as an oil which was used without further purification in Step B.

Workup

  1. temperatureheated at an oil bath temperature of 100° for 96 hours
  2. customThe mixture was evaporated under reduced pressure
  3. extractionThe aqueous phase was extracted with methyl acetate
  4. customdried
  5. customevaporated

Sources & evidence

ORD record
ord-a0732057141d41f5b901fbd67e6d3a42
Source dataset
uspto-grants-1984_09
Patent number
US04471122

Reaction notes

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