Hydrazine hydrate (1:1) → HCID 178512516, compound

HRID 2418115Notes

Reaction equation

HRID 2418115 reaction equation
Cl.[NH:2]([C:6]1[CH:7]=[C:8]([CH:24]=[CH:25][CH:26]=1)[O:9][CH2:10][CH2:11][CH2:12][N:13]1C(=O)C2=CC=CC=C2C1=O)[C:3]([NH2:5])=[NH:4].O.NN>C(O)C>[NH:2]([C:6]1[CH:7]=[C:8]([CH:24]=[CH:25][CH:26]=1)[O:9][CH2:10][CH2:11][CH2:12][NH2:13])[C:3]([NH2:5])=[NH:4]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 178479378HCID 178479378, compound

Product 1

HCID 178512516HCID 178512516, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a partial suspension of N-[3-(3-guanidinophenoxy)propyl]phthalimide hydrochloride (1.0 g; 2.95 mmoles) in 10 ml of 95% aqueous ethanol was added 0.27 ml of hydrazine hydrate. The mixture was stirred at ambient temperature for 17 hours and evaporated under reduced pressure to give the title compound. The product was used without further purification in Step E.

Workup

  1. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-8285829504964e79a01af77109153c21
Source dataset
uspto-grants-1984_09
Patent number
US04471122

Reaction notes

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