Hydrochloric Acid → HCID 86739642, compound

Participants

Reaction Steps

2-[4-(2-Phenylacetoxy)phenyl]-2-[3-[2-{4-(3-carboxy-3-tritylaminopropoxy)phenyl}-2-hydroxyiminoacetamido]-2-oxo-1-azetidinyl]acetic acid (0.5 g.) was dissolved in 80% acetic acid (10 ml.) and the mixture was stirred for 45 minutes. Insoluble materials were filtered off from the reaction mixture and the filtrate was evaporated to dryness under reduced pressure. The residue obtained was triturated with ethyl acetate to give a powder (0.27 g.). This powder (0.2 g.) was dissolved in an aqueous sodium bicarbonate and the solution was adjusted to pH 3 with 10% hydrochloric acid to give crystals of 2-[3-[2-{4-(3-amino-3-carboxypropoxy)phenyl}-2-hydroxyiminoacetamido]-2-oxo-1-azetidinyl]-2-[4-(2-phenylacetoxy)phenyl]acetic acid (0.14 g.).

Provenance & Evidence