反应详情

2.3 g of commercially available 85% strength m-chloroperoxybenzoic acid, dissolved in 30 ml of methylene chloride, are added dropwise to a solution, cooled to -30° C., of 3.0 g (0.0088 mole) of 4-trifluoromethyl-2-[(4-methoxy-2-pyridylmethyl)thio]-(1H)-benzimidazole in 50 ml of methylene chloride over the course of 45 minutes. The resulting mixture is then stirred for a further 60 minutes, and the temperature is subsequently allowed to rise to 0° C. After the mixture is washed with saturated aqueous sodium carbonate solution (30 ml), it is dried over sodium sulfate, and the solvent is stripped off in vacuo. The solid residue which remains is recrystallized successively from isopropanol and acetonitrile. Yield: 1.6 g of title compound, m.p. 150° to 151° C.

1. additionare added dropwise to a solution
2. customto rise to 0° C
3. washAfter the mixture is washed with saturated aqueous sodium carbonate solution (30 ml), it
4. dry with materialis dried over sodium sulfate
5. customThe solid residue which remains is recrystallized successively from isopropanol and acetonitrile