Sodium hydride → HCID 178493209, compound

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Reaction Steps

0.09 g (0.003 mole) of 80% sodium hydride (in paraffin) are added to a solution of 1.1 g of 5-trifluoromethyl-2-[(4-methoxy-2-pyridylmethyl)-sulfinyl]-(1H)-benzimidazole in 20 ml of dry dioxan under an inert gas atmosphere. After the evolution of gas has subsided, the solvent is stripped off in vacuo. The residue (5-trifluoromethyl-2-[(4-methoxy-2-pyridylmethyl)-sulfinyl]-(1H)-benzimidazole sodium salt) is dissolved in a little water, and a 1% strength aqueous calcium chloride solution is added. The precipitate which has separated out is filtered off with suction and dried in a high-vacuum for several hours. M.p. 176° C. (decomposition).

Provenance & Evidence