Sodium hydride → HCID 178493209, compound

HRID 2418251Notes

Reaction equation

HRID 2418251 reaction equation
[H-].[Na+].[F:3][C:4]([F:26])([F:25])[C:5]1[CH:24]=[CH:23][C:8]2[NH:9][C:10]([S:12]([CH2:14][C:15]3[CH:20]=[C:19]([O:21][CH3:22])[CH:18]=[CH:17][N:16]=3)=[O:13])=[N:11][C:7]=2[CH:6]=1.[Na].FC(F)(F)C1C=CC2NC(S(CC3C=C(OC)C=CN=3)=O)=NC=2C=1.[Cl-].[Ca+2:53].[Cl-]>O1CCOCC1.O>[Ca:53].[F:26][C:4]([F:3])([F:25])[C:5]1[CH:24]=[CH:23][C:8]2[NH:9][C:10]([S:12]([CH2:14][C:15]3[CH:20]=[C:19]([O:21][CH3:22])[CH:18]=[CH:17][N:16]=3)=[O:13])=[N:11][C:7]=2[CH:6]=1

Participants

7

Reactant 4

HCID 24758Sodium hydrideHCID 5284359Calcium ChlorideHCID 178493208HCID 178493208, compoundHCID 178493210HCID 178493210, compound

Product 1

HCID 178493209HCID 178493209, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

0.09 g (0.003 mole) of 80% sodium hydride (in paraffin) are added to a solution of 1.1 g of 5-trifluoromethyl-2-[(4-methoxy-2-pyridylmethyl)-sulfinyl]-(1H)-benzimidazole in 20 ml of dry dioxan under an inert gas atmosphere. After the evolution of gas has subsided, the solvent is stripped off in vacuo. The residue (5-trifluoromethyl-2-[(4-methoxy-2-pyridylmethyl)-sulfinyl]-(1H)-benzimidazole sodium salt) is dissolved in a little water, and a 1% strength aqueous calcium chloride solution is added. The precipitate which has separated out is filtered off with suction and dried in a high-vacuum for several hours. M.p. 176° C. (decomposition).

Workup

  1. customThe precipitate which has separated out
  2. filtrationis filtered off with suction
  3. customdried in a high-vacuum for several hours

Sources & evidence

ORD record
ord-484271dc05b44f4dbb43fe34149b5f1c
Source dataset
uspto-grants-1984_09
Patent number
US04472409

Reaction notes

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