Bromine → 3-[2-Bromo-4-(1,1-dimethyl-pentyl)-phenyl]-2-methylpropyl chloride

HRID 2418276Notes

Reaction equation

HRID 2418276 reaction equation
[Br:1]Br.[CH3:3][C:4]([C:10]1[CH:15]=[CH:14][C:13]([CH2:16][CH:17]([CH3:20])[CH2:18][Cl:19])=[CH:12][CH:11]=1)([CH3:9])[CH2:5][CH2:6][CH2:7][CH3:8]>C(Cl)Cl.[Fe]>[Br:1][C:14]1[CH:15]=[C:10]([C:4]([CH3:3])([CH3:9])[CH2:5][CH2:6][CH2:7][CH3:8])[CH:11]=[CH:12][C:13]=1[CH2:16][CH:17]([CH3:20])[CH2:18][Cl:19]

Participants

5

Reactant 2

HCID 24408BromineHCID 13141993HCID 13141993, compound

Product 1

HCID 131419943-[2-Bromo-4-(1,1-dimethyl-pentyl)-phenyl]-2-methylpropyl chlorideYield 56.6%

Reagents, catalysts & solvents 2

HCID 23925IronCatalystHCID 6344DichloromethaneSolvent

Procedure

180 g of Br2 were added dropwise to amixture of 300 g of XII and 3 g of Fe powder at room temperature, and the mixture was stirred for 14 hours at room temperature. The crude product was dissolved in CH2Cl2, and the solution was washed with water, dried over Na2SO4 and distilled. 220 g of (XIII) of boiling point 160° C./0.1 mbar were obtained.

Workup

  1. washthe solution was washed with water
  2. dry with materialdried over Na2SO4
  3. distillationdistilled

Sources & evidence

ORD record
ord-9383dc6049564916a38af0d1196ac0ca
Source dataset
uspto-grants-1984_09
Patent number
US04472412

Reaction notes

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