1,1-Dimethylhydrazine → HCID 22827696, compound

HRID 2418300Notes

Reaction equation

HRID 2418300 reaction equation
[CH3:1][O:2][C:3](=[O:28])[C@H:4]([CH3:27])[N:5]([C:13](=[O:26])[CH2:14]OS(C1C=CC(C)=CC=1)(=O)=O)[C:6]1[C:10]([CH3:11])=[CH:9][S:8][C:7]=1[CH3:12].[CH3:29][N:30]([CH3:32])[NH2:31]>C(O)C>[CH3:1][O:2][C:3](=[O:28])[C@H:4]([CH3:27])[N:5]([C:13](=[O:26])[CH2:14][NH:31][N:30]([CH3:32])[CH3:29])[C:6]1[C:10]([CH3:11])=[CH:9][S:8][C:7]=1[CH3:12]

Participants

4

Reactant 2

HCID 59761,1-DimethylhydrazineHCID 22827699HCID 22827699, compound

Product 1

HCID 22827696HCID 22827696, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 8.5 g (0.02 mol) N-[(4-methylphenyl)-sulphonyloxyacetyl]-N-(2,4-dimethylthien-3-yl)-alanine-methylester (=Ex. 3.9) and 2.4 g (0.04 mol) 1,1-dimethylhydrazine in 150 ml ethanol is refluxed for four hours, then evaporated in vacuo, the residue taken up in dichloromethane, washed subsequently with water, aqueous 1 N HCl and water, dried over MgSO4, and evaporated in vacuo to yield the title compound.

Workup

  1. temperatureis refluxed for four hours
  2. customevaporated in vacuo
  3. washwashed subsequently with water, aqueous 1 N HCl and water
  4. dry with materialdried over MgSO4
  5. customevaporated in vacuo

Sources & evidence

ORD record
ord-e249df68c59443d98eebfd4c343b3139
Source dataset
uspto-grants-1984_09
Patent number
US04472425

Reaction notes

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