Hydrochloric Acid → HCID 20446134, compound

HRID 2418305Notes

Reaction equation

HRID 2418305 reaction equation
[CH3:1][C:2]1[S:3][CH:4]=[C:5]([CH3:9])[C:6]=1[NH:7][NH2:8].N1C=CC=CC=1.[OH2:16].Cl.[CH2:18]([O:20][CH2:21]C)C>>[CH3:1][C:2]1[S:3][CH:4]=[C:5]([CH3:9])[C:6]=1[NH:7][NH:8][C:18]([O:20][CH3:21])=[O:16]

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 962Water2×HCID 1049PyridineHCID 3283Diethyl EtherHCID 20446133HCID 20446133, compound

Product 1

HCID 20446134HCID 20446134, compound

Procedure

To a mixture of 35.5 g (0.25 mol) 2,4-dimethylthien-3-yl-hydrazine, 27.6 g (0.35 mol) pyridine and 83 ml water are added within 15 minutes at room temperature 23.6 g (0.25 mol) methyl chloroformiate. 83 ml water are further added, and the mixture is stirred for 3 hours at room temperature. After the addition of 300 ml diethylether, the mixture is acidified with 2 N HCl, the organic phase separated, washed with water, dried and concentrated.

Workup

  1. additionare added within 15 minutes at room temperature 23.6 g (0.25 mol) methyl chloroformiate
  2. customthe organic phase separated
  3. washwashed with water
  4. customdried
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-1e8f886e492d493e9ec3363a0a41cf74
Source dataset
uspto-grants-1984_09
Patent number
US04472425

Reaction notes

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