Ammonium Hydroxide → HCID 21791728, compound

HRID 2418306Notes

Reaction equation

HRID 2418306 reaction equation
C(C1C=CC(N[N:10]=[C:11]2[C:16]3=[N:17][C:18]4[C:23]([C:24](=[O:25])[N:15]3[CH2:14][CH2:13][CH2:12]2)=[CH:22][CH:21]=[CH:20][CH:19]=4)=CC=1)#N.[OH-].[NH4+:27]>O>[C:24]([C:23]1[CH:22]=[C:21]2[C:12]3[CH2:13][CH2:14][N:15]4[C:24](=[O:25])[C:23]5[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=5[N:17]=[C:16]4[C:11]=3[NH:10][C:20]2=[CH:19][CH:18]=1)#[N:27]

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 57140842HCID 57140842, compound

Product 1

HCID 21791728HCID 21791728, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1 g of 6-[(4-Cyano-phenyl)-hydrazono]-6,7,8,9-tetrahydro-11H-pyrido[2,1-b]quinazoline-11-one is heated in 10 g of polyphosphoric acid at 180° C. for 30 minutes. After cooling the reaction mixture is diluted with 40 ml of water and the pH is adjusted to 5 by adding 25 V/W% ammoniumhydroxide solution. The precipitated product is filtered, washed with water and dried. 0.88 g (92%) of 10-cyano-7,8-dihydro-5H,13H-indolo[2',3';3,4]pyrido[2,1-b]quinazoline-5-one are obtained which after recrystallization from dimethylformamide melts at 255° C.

Workup

  1. temperatureAfter cooling the reaction mixture
  2. filtrationThe precipitated product is filtered
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-be9a9bd705e347b4b2de6528de59d39c
Source dataset
uspto-grants-1984_09
Patent number
US04472399

Reaction notes

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