Sodium Hydroxide → HCID 86739649, compound

HRID 2418317Notes

Reaction equation

HRID 2418317 reaction equation
NCC([NH:5][C:6]1[CH:11]=[CH:10][C:9]([C:12](=[N:14][OH:15])[CH3:13])=[CH:8][C:7]=1[C:16](=[N:24][OH:25])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[F:23])=O.[OH-].[Na+]>>[NH2:5][C:6]1[CH:11]=[CH:10][C:9]([C:12](=[N:14][OH:15])[CH3:13])=[CH:8][C:7]=1[C:16](=[N:24][OH:25])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[F:23]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 86739650HCID 86739650, compound

Product 1

HCID 86739649HCID 86739649, compound

Procedure

10 g (26.26 mmol) of 2-amino-2'-[o-fluoro-α-(hydroxyimino)benzyl]-4'-[1-(hydroxyimino)ethyl]-acetanilide are treated with 3N sodium hydroxide at 50° for 1 hour. The pH of the solution is adjusted to 8 and the precipitated material is filtered off, washed with water and dried at 50° in vacuo over phosphorus pentoxide. There is obtained 2-amino-2'-fluoro-5-[1-(hydroxyimino)ethyl]benzophenone oxime as a foam of melting point ca 165°.

Workup

  1. filtrationthe precipitated material is filtered off
  2. washwashed with water
  3. dry with materialdried at 50° in vacuo over phosphorus pentoxide

Sources & evidence

ORD record
ord-7c19d9c1c0f045b59cda9747563f1f1f
Source dataset
uspto-grants-1984_09
Patent number
US04472435

Reaction notes

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