反应详情

温度

120 °C

A mixture of ethyl 2-(2-nitro-3-chlorophenyl)acetate (15 g.), phenol (6.4 g.), anhydrous potassium carbonate (13 g.) and cupric oxide (4.5 g.) was stirred for 4 hours at 120° C. To the reaction mixture was added water and the mixture was extracted with diethyl ether. The extract was washed with a diluted aqueous solution of potassium carbonate and water, dried over magnesium sulfate and then evaporated under reduced pressure. The oily residue was distilled under reduced pressure to give ethyl 2-(2-nitro-3-phenoxypheny)acetate (5.2 g.) bp 160°-183° C./0.4 mmHg.

1. extractionthe mixture was extracted with diethyl ether
2. washThe extract was washed with a diluted aqueous solution of potassium carbonate and water
3. dry with materialdried over magnesium sulfate
4. customevaporated under reduced pressure
5. distillationThe oily residue was distilled under reduced pressure