HCID 20446227, compound → HCID 20446171, compound

HRID 2418336Notes

Reaction equation

HRID 2418336 reaction equation
[O:1]=[C:2]1[CH:10](SC)[C:9]2[C:4](=[C:5]([O:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[NH2:20])[CH:6]=[CH:7][CH:8]=2)[NH:3]1>[Ni].O1CCOCC1>[O:1]=[C:2]1[CH2:10][C:9]2[C:4](=[C:5]([O:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[NH2:20])[CH:6]=[CH:7][CH:8]=2)[NH:3]1

Participants

4

Reactant 1

HCID 20446227HCID 20446227, compound

Product 1

HCID 20446171HCID 20446171, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 312751,4-DioxaneSolvent

Procedure

A mixture of 2-oxo-3-methylthio-7-(2-aminophenoxy)indoline (4.5 g.), Raney nickel (W-2 type)(9 ml.) and dioxane (50 ml.) was treated in a similar manner to that of the Preparation 15-(2) to give the captioned compound (3.5 g.) mp 210° to 212° C.

Workup

  1. additionwas treated in a similar manner to that
  2. customof the Preparation 15-(2)
  3. customto give the captioned compound (3.5 g.) mp 210° to 212° C.

Sources & evidence

ORD record
ord-c457461232a94a7c91ec0a80520b6c20
Source dataset
uspto-grants-1984_09
Patent number
US04472433

Reaction notes

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