Diethylamine → N,N-diethyl-2-[2-nitro-3-(2-fluorophenoxy)phenyl]acetamide

HRID 2418342Notes

Reaction equation

HRID 2418342 reaction equation
[N+:1]([C:4]1[C:9]([O:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[F:17])=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:18][C:19]([OH:21])=O)([O-:3])=[O:2].P(Cl)(Cl)(Cl)(Cl)Cl.[CH2:28]([NH:30][CH2:31][CH3:32])[CH3:29]>>[CH2:28]([N:30]([CH2:31][CH3:32])[C:19](=[O:21])[CH2:18][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]([O:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[F:17])[C:4]=1[N+:1]([O-:3])=[O:2])[CH3:29]

Participants

4

Reactant 3

HCID 8021DiethylamineHCID 24819Phosphorus pentachlorideHCID 204461882-[2-Nitro-3-(2-fluorophenoxy)phenyl]acetic acid

Product 1

HCID 20446214N,N-diethyl-2-[2-nitro-3-(2-fluorophenoxy)phenyl]acetamide

Procedure

2-[2-Nitro-3-(2-fluorophenoxy)phenyl]acetic acid (4 g.), phosphorus pentachloride (3.1 g.) and diethylamine (3 g.) were treated in a similar manner to that of the Preparation 33 to give the oily captioned compound (5.2 g.).

Workup

  1. customof the Preparation 33
  2. customto give the oily captioned compound (5.2 g.)

Sources & evidence

ORD record
ord-a6484c1cc5df44de943d0aa8a306728e
Source dataset
uspto-grants-1984_09
Patent number
US04472433

Reaction notes

Loading…