反应详情

A mixture of ethyl 2-[2-amino-3-(2-chlorophenoxy)phenyl]acetate (4.3 g.), sodium hydroxide (1.1 g.) and water (50 ml.) was refluxed under heating for 5 hours with stirring. The reaction mixture was left to cool at ambient temperature and washed with diethyl ether. To the aqueous solution was added diethyl ether, and the mixture was adjusted to ph 4 with 5% sulfuric acid. The diethyl ether layer was separated, washed with water and dried over magnesium sulfate and then the solvent was distilled off under reduced pressure. The residue (3.4 g.) was crystallized with a mixture of benzene and n-hexane to give 2[2-amino-3-(2-chlorophenoxy)phenyl]acetic acid (1.9 g.). mp 86° to 90° C.

1. temperaturewas refluxed
2. temperatureunder heating for 5 hours
3. waitThe reaction mixture was left
4. washwashed with diethyl ether
5. additionTo the aqueous solution was added diethyl ether
6. customThe diethyl ether layer was separated
7. washwashed with water
8. dry with materialdried over magnesium sulfate
9. distillationthe solvent was distilled off under reduced pressure
10. customThe residue (3.4 g.) was crystallized with a mixture of benzene and n-hexane