Sodium Hydroxide → HCID 20446142, compound

Participants

Reaction Steps

A mixture of ethyl 2-[2-amino-3-(2-chlorophenoxy)phenyl]acetate (4.3 g.), sodium hydroxide (1.1 g.) and water (50 ml.) was refluxed under heating for 5 hours with stirring. The reaction mixture was left to cool at ambient temperature and washed with diethyl ether. To the aqueous solution was added diethyl ether, and the mixture was adjusted to ph 4 with 5% sulfuric acid. The diethyl ether layer was separated, washed with water and dried over magnesium sulfate and then the solvent was distilled off under reduced pressure. The residue (3.4 g.) was crystallized with a mixture of benzene and n-hexane to give 2[2-amino-3-(2-chlorophenoxy)phenyl]acetic acid (1.9 g.). mp 86° to 90° C.

Provenance & Evidence